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BI4.1-8 | Chemistry and Metabolism of Lipids — Practice Quiz

Practice 10 questions · Untimed · Unlimited attempts

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Q1 BI4.1 1 pt

Which class of lipids serves as the primary energy storage form in the human body?

A Phospholipids
B Triacylglycerols (triglycerides)
C Cholesterol esters
D Glycolipids

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Q2 BI4.2 1 pt

Which of the following fatty acids is classified as an essential fatty acid that must be obtained from the diet?

A Palmitic acid (C16:0)
B Oleic acid (C18:1)
C Linoleic acid (C18:2, omega-6)
D Stearic acid (C18:0)

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Q3 BI4.3 1 pt

CPT-I (carnitine palmitoyltransferase I) is the rate-limiting step of beta-oxidation. Which molecule inhibits CPT-I, thereby preventing fatty acid oxidation when synthesis is active?

A Acetyl-CoA
B Malonyl-CoA
C Citrate
D Palmitoyl-CoA

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Q4 BI4.4 1 pt

Acetyl-CoA carboxylase (ACC) catalyses the rate-limiting step of fatty acid synthesis. Which vitamin is required as a cofactor for this enzyme?

A Thiamine (B₁)
B Pyridoxine (B₆)
C Biotin (B₇)
D Cobalamin (B₁₂)

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Q5 BI4.3 1 pt

A 2-year-old child presents with altered sensorium after a 14-hour fast. Blood glucose is 35 mg/dL and urine ketones are NEGATIVE. Which enzyme deficiency is the most likely diagnosis?

A Glucose-6-phosphatase deficiency
B Carnitine palmitoyltransferase II (CPT-II) deficiency
C Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency
D HMG-CoA lyase deficiency

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Q6 BI4.5 1 pt

HMG-CoA reductase catalyses the rate-limiting step of cholesterol biosynthesis. Which drug class inhibits this enzyme to lower blood cholesterol?

A Fibrates
B Bile acid sequestrants
C Statins
D PCSK9 inhibitors

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Q7 BI4.7 1 pt

Which lipoprotein is responsible for 'reverse cholesterol transport' — carrying excess cholesterol from peripheral tissues back to the liver?

A Chylomicrons
B VLDL
C LDL
D HDL

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Q8 BI4.6 1 pt

A premature neonate develops respiratory distress syndrome (RDS) due to deficiency of pulmonary surfactant. The major phospholipid component of surfactant is:

A Sphingomyelin
B Dipalmitoylphosphatidylcholine (DPPC/lecithin)
C Phosphatidylserine
D Phosphatidylinositol

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Q9 BI4.8 1 pt

A 42-year-old man presents with an LDL of 210 mg/dL and triglycerides of 380 mg/dL. He is started on atorvastatin. By which mechanism does atorvastatin primarily reduce blood LDL levels?

A Directly blocks LDL production by the liver
B Inhibits HMG-CoA reductase → liver upregulates LDL receptors → increased LDL clearance from blood
C Blocks intestinal cholesterol absorption via NPC1L1
D Activates PPARα to increase fatty acid oxidation

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Q10 BI4.7 1 pt

A patient's fasting lipid profile shows: Total cholesterol 250 mg/dL, LDL 170 mg/dL, HDL 32 mg/dL, Triglycerides 450 mg/dL. The serum appears milky (lipaemic). Which lipoprotein is most likely elevated to cause the milky appearance?

A LDL
B HDL
C VLDL (and possibly residual chylomicrons)
D Lipoprotein(a)

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